1 - Pediatric Infectious Diseases Unit, Hospital Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal
- 9th Congress of the European Academy of Paediatric Societies (EAPS 2022) (E-Poster Discussion)
Background: Multisystem inflammatory syndrome in children (MIS-C) emerged after the beginning of COVID-19 pandemics. Therefore, there is a lack of data about this entity, as well as possible sequelae at follow-up.
Aim: To describe the characteristics of children admitted to a tertiary hospital and their follow-up.
Methods: Observational, descriptive study of MIS-C patients from April 2020 to February 2022 (22 months).
Results: We report 76 patients with MIS-C, the median age was 6,3 years [10 months-17,5 years], 69,7% were male and 22,4% (17/76) were admitted in the intensive care. At admission, 100% had fever, 90,8% gastrointestinal symptoms, and 72,4% mucocutaneous involvement. During hospitalization, cardiac involvement was verified in 92,1%, hepatitis in 60,5%, kidney involvement in 27,6%, respiratory involvement in 13,2% and neurologic involvement in 9,2%. All patients had high inflammatory markers and coagulopathy (100%), 89,2% hypoalbuminemia, 86,8% anemia, 76,3% neutrophilia, 73,7% high levels of lactate dehydrogenase, 64,5% lymphopenia, and 64,5% thrombocytosis. Treatment involved intravenous immunoglobulin (81,6%), corticotherapy (77,6%), antibiotherapy (93,4%) and antiaggregation/anticoagulation (73,7%). Regarding the severity of the disease, 22,4% was mild (17/76), 55,2% moderate (42/76) and 22,4% severe (17/76). Changes were seen in thoracic x-ray (52,6%), abdominal ultrasonography (98,7%), electrocardiography (38,2%) and echocardiography (43,1%). At follow-up (61/76 was observed), 60,7% had cardiac changes, 29,5% DMSA scan changes and 8,2% pulmonary function changes. Physiotherapy was necessary in 14,8%, nutritional support in 16,4% and psychological support in 14,8%.
Conclusion: We describe the clinical presentation and short-term outcomes of MIS-C. Further studies are needed to understand if the changes observed at follow-up will be reversible.
Palavras Chave: COVID-19; multisystem inflammatory syndrome in children; SARS-CoV-2