1. Serviço de Imunoalergologia, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal
2. Grupo de Interesse Alergénios e Imunoterapia, Sociedade Portuguesa de Alergologia e Imunologia Clínica, Lisboa, Portugal
3. Serviço de Imunologia, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
4. Serviço de Imunoalergologia, Hospital São Bernardo, Setúbal, Portugal
5. Serviço de Imunoalergologia, Hospital do Espírito Santo de Évora, Évora, Portugal
6. Serviço de Imunoalergologia, Hospital de Portimão, Centro Hospitalar Universitário do Algarve, Portimão, Portugal
7. Serviço de Imunoalergologia, Hospital Prof. Doutor Fernando Fonseca, Amadora-Sintra, Portugal
8. Serviço de Imunoalergologia, Hospital de Aveiro, Centro Hospitalar Baixo Vouga, Aveiro, Portugal
9. Serviço de Imunoalergologia, Hospital de Santo António, Centro Hospitalar do Porto, Porto, Portugal
10. Serviço de Imunoalergologia, Hospital das Forças Armadas, Lisboa, Portugal
11. Serviço de Imunoalergologia, Hospital de Faro, Centro Hospitalar Universitário do Algarve, Faro, Portugal
12. Serviço de Imunoalergologia, Unidade Local de Saúde de Castelo Branco, Castelo Branco, Portugal
13. Serviço de Imunoalergologia, Hospital Dona Estefânia, Centro Hospitalar Lisboa Central, Lisboa, Portugal
14. Serviço de Imunoalergologia, Centro Hospitalar Universitário de São João, Porto, Portugal
15. Serviço de Imunoalergologia, Centro Hospitalar Universitário Cova da Beira, Covilhã, Portugal
16. Laboratório de Imunologia Clínica, Faculdade de Medicina, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal
17. Clínica Universitária de Imunoalergologia, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal
18. Diater laboratorios, Madrid, Spain
- Reunião Internacional, apresentação sob a forma de comunicação oral, European Academy of Allergy and Clinical Immunology Annual Congress Lisboa, 1-5 de Julho de 2019
Background: In Portugal, dust mite (DM) allergens, namely those of Dermatophagoides pteronyssinus (Dp), are the most prevalent ones. Aim: to analyse component-resolved diagnosis (CRD) to Dp (rDer p 1, rDer p 2, rDer p 10 and rDer p 23) in patients with respiratory allergy to DM, and possible relationship with clinical severity and geographical areas.
Method: We selected 217 patients in 13 centres in Portugal, 5 from North (n=65) and 8 from South (n=152). These patients had allergic rhinitis, with or without asthma, positive SPT to at least one of the DM - Dp, D. farinae (Df), L.destructor (Ld) or B.tropicalis, and had never undergone immunotherapy with DM. sIgE to Dp, Df and Lp, and CRD to Der p 1, Der p 2, Der p 10 and Der p 23 were determined using ImmunoCAP-ThermoFisher Scientific. Statistical analysis was performed with Mann Whitney U test (rhinitis vs rhinitis+asthma; mild vs moderate/severe rhinitis; Northern centres vs Southern centres).
Results: 217 patients (mean age 25.85±12.7 years; 51.16% females). For all DM, prevalence (patients with sIgE >0.35kU/L) was 98.2% for Dp, 97.2% for Df and 84.8% for Lp, while corresponding serodominance (median levels of sIgE - kU/L) was 31.9,17.5 and 8.12. For CRD, prevalence of Der p 1, Der p 2, Der p 10 and Der p 23 was 72.4%, 89.4%, 9.7% and 77%, respectively, while corresponding serodominance was 8.56, 17.7, 0.01 and 3.95. Table 1 shows median serum levels of sIgE according to clinical severity and geographical areas.
Conclusion: We confirmed that Dp sensitisation is the most common one in Portugal. The most prevalent CRD is Der p 2, followed by Der p 23, Der p 1 and Der p 10. The major serodominance belongs to Der p 2, followed by Der p 1,Der p 23 and Der p 10. Although sIgE levels for these CRD were higher in more symptomatic patients, this trend was not statistically significant. The median level of sIgE to Der p 2 in the Southern centres was higher and statistically significant when compared with Northern centres, which may be related to the largest sample of this region.