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2021

ANUÁRIO DO HOSPITAL
DONA ESTEFÂNIA

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POSTINFECTIOUS ENCEPHALITIS AFTER PEDIATRIC HERPETIC ENCEPHALITIS TREATED WITH INTERFERON. WHAT IS THE TRIGGERING FACTOR?

Rosário Perry1, Rita Silva2, Carla Conceição3, Flora Candeias1, Ana Moreira2, Maria João Brito1

1 - Unidade de Infecciologia, 2 - Serviço de Neurologia, 3 - Serviço de Imagiologia, Hospital de Dona Estefânia, Centro Hospitalar de Lisboa Central, EPE, Lisboa

  • 31st Annual Meeting of the European Society for PaediatricInfeccious Diseases (ESPID 2013). Milão, Itália 28 Mai-1 Jun 2013

Background: Postinfectious encephalitis (PIE) is an immune process caused by deregulation of the immune system following infection or immunization. Acute secondary neurological deterioration after herpes simplex encephalitis has been reported.
Methods:We discuss a case of PIE after herpetic encephalitis treated withinterferonafterrespiratoryinfectionand vaccination.
Results: 12 month-old otherwise healthy child presented with vomiting, fever, tonic seizures, altered state of consciousness (Glasgow 8) and left hemiparesis. MRI showed multiple cortical lesions in temporal, parietal and occipital lobes. PCR HSV-1 in CSF was positive. Acyclovirwas startedon D2(21 days) and per protocol interferon alfa-2b on D3 (10 days) withoutcomplications. She was discharged clinicallyasymptomatic with prophylactic acyclovir and antiepileptic drugs.
Two weeks later she had an upper respiratory infection. Also, live attenuated MMR vaccination was undertaken. Fiveweeks followingherpeticencephalitis, she revealed irritability alternated with sleepiness, no interest on interacting, superior left limb and cervical choreiform movements, axial ataxia and stereotypies. Electroencephalography showed paroxysmal right predominant bifrontal activity. MRI showed deterioration of previous abnormalities with extensive white matter lesions, suggesting possible immune-mediated demyelization. PCR HSV-1 and measles in CSF was negative but oligoclonal bands in serum and CSF were found. She was treated with corticosteroids and human immunoglobulin with both clinical and imagiological improvement.
Discussion: An immune mediated process better explains the pathogenesis of this relapse. It may be due to the herpetic encephalitis itself or induced by interferon treatment, but viral infection or live vaccination cannot be overruled as triggering factors.

Keywords: postinfectious encephalitis, herpes simplex