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2020

ANUÁRIO DO HOSPITAL
DONA ESTEFÂNIA

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CHARACTERIZATION OF LIPODYSTROPHY AND METABOLIC DISORDERS IN PORTUGUESE CHILDREN WITH HIV INFECTION

Maria João Brito2, Ana Catarina Guerra2, Maria Conceição Neves1,2, Flora Candeias1,2

1 Immunodeficiency Consultation
2 Pediatric Infectious Diseases Unit

Hospital Dona Estefânia – CHLC - EPE, Lisbon, Portugal

8th World Congress of the Society for Pediatric Infectious Diseases, 19-22 Nov 2013, Cape Town, South Africa (poster)

Background and aims
In Portugal, by 2011, 3,3% cases of HIV infection were registered under 19.Prolonged exposure to antiretroviral drugs has highlighted the toxic effects of drugs like lipodystrophy syndrome (LD), often associated with metabolic complications. Studies of LD in children have been small and estimated prevalence varies from 10-65%.
Our aim is to characterize the prevalence of LD and metabolic disturbances in a sample of portuguese children with HIV infection.

Methods
A cross sectional-study included 96 patients with HIV infection under 19, followed in a single portuguese center.Demographics, Tanner stage, immunologicaland virologicalstatus, HAART data, lipid profile, BMI and clinical signs of LD were recorded. SPSS was used for statistic analyze.

Results
An average age of 13,8yrs old, 52,5% of male and predominance(45,5%) of VTanner stage was obtained.Most children(87,5%) was receiving HAART, with viral suppression in 67%.They used, on average, 2 previous HAART schemes. The prevalence of LD was 10,1%(95%CI: 4,31–16,53) and BMI Zscore>1 in 20.6%(95%CI: 11,28-29,82). LDL>130mg/dlin 25,3%(95%CI: 17,26-34,82) children, HDL<45mg/dlin 42,4%(95%CI: 33,83-53,67), triglycerides(TG)>150mgin 22,2%(95%CI: 14,51-31,33).
LD was statistically related to HAART schemesnumber(p = 0.009), high TG value (p = 0.017) and low HDL value(p = 0.01). Physical exercise was none or light in 60.6%(95%CI: 50,98-70,23)and did not statistically correlate with the LD or lipid profile disturbance.

Conclusions
A low prevalence of LD was described, related to the number of previous drugs, instead of specific antiretrovirals. Lipid profile disorders and overweight were more prevalent and should be actively controlled.

Key-words: HIV infection, lipodystrophy syndrome