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2020

ANUÁRIO DO HOSPITAL
DONA ESTEFÂNIA

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AUTISM SPECTRUM DISORDER SECONDARY TO ENTEROVIRUS ENCEPHALITIS

Filipa Marques1, Maria João Brito1, Marta Conde1, Mónica Pinto2, Ana Moreira3

1 Infectious Diseases Unit, 2 Child Development Centre, 3 Paediatric Neurology Unit, Hospital Dona Estefânia, Centro Hospitalar Lisboa, Central–EPE,

Aceite para publicação no Journal of Child Neurology (artigo)

Abstract
Millions of children are infected by enteroviruses each year, usually exhibiting only mild symptoms. Nevertheless, these viruses are also associated with severe and life-threatening infections, such as meningitis and encephalitis. We describe a 32-month-old patient with enteroviral encephalitis confirmed by polymerase chain reaction in cerebrospinal fluid, with unfavorable clinical course with marked developmental regression, autistic features, persistent stereotypes and aphasia. She experienced slow clinical improvement, with mild residual neurologic and developmental deficits at follow-up. Viral central nervous system infections in early childhood have been associated with autism spectrum disorders but the underlying mechanisms are still poorly understood.
This case report is significant in presenting a case of developmental regression with autistic features and loss of language improving on follow-up. To our knowledge, this is the first published report of enterovirus encephalitis leading to an autism spectrum disorder.

Keywords: enterovirus, encephalitis, children, autism spectrum disorder