1 - Department of Pediatrics, Hospital Dona Estefânia, , Centro Hospitalar Universitário de Lisboa Central, Lisboa
2 - Pediatric Gastroenterology Unit, Hospital Dona Estefania, , Centro Hospitalar Universitário de Lisboa Central, Lisboa
- Publicação em versão integral
Resumo: Cow’s protein milk allergy is the most common food allergy in infants (2%–3% of the infant population), typically occurring in the first 6 months of life. Family history of atopy, prematurity or previous use of antibiotics are possible risk factors for CPMA. Common non-immunoglobulin E-mediated symptoms include vomiting, regurgitation, diarrhoea, rectal bleeding and irritability in an otherwise healthy infant. A 34-day-old male infant, previously breast fed, with a clinical background of late prematurity (35 weeks), was small for gestational age, requiring hospitalisation to achieve feeding autonomy, and at 21 days old due to urinary tract infection. He had a 5-day history of mucus, bloody diarrhoea, irritability and frequent regurgitation, which started 1 day after consuming an infant formula and did not improve even after consuming an extensively hydrolysed (EH) formula for 2 days. General examination was unremarkable, including the presence of bowel sounds and depressible abdomen without visible collateral circulation. Sepsis screening on blood tests was negative. Stool culture was negative for Salmonella, Shigella and Campylobacter, as was the antigen detection of rotavirus, adenovirus, astrovirus and Norwalk. Abdominal radiography revealed pneumatosis intestinalis (PI), and abdominal ultrasound revealed aeroportia. Empirical, intravenous antibiotic therapy (cefotaxime, gentamicin and metronidazole) was initiated to treat gram-negative, gram-positive and anaerobic bacteria. He was on total parenteral nutrition exclusively for 3 days. After 48 hours, the mucus and bloody diarrhoea stopped, and findings of abdominal radiography and ultrasound were normal. EH was slowly reintroduced; however, the infant had frequent episodes of regurgitation with facial congestion and cyanosis, which improved after switching to a thickened amino acid-based formula (AAF) and starting esomeprazole. He was discharged after 10 days of antibiotic therapy, with favourable outcomes. Through his first year, attempts to reintroduce cow’s milk protein led to resumption of symptomatic oesophageal reflux and the need to continue with AAF, resulting in a failure to thrive. In term or near-term infants, CPMA and necrotising enterocolitis may be difficult to differentiate based on the initial symptoms. In this case, the presence of bloody stools and PI suggested NEC, and it was treated initially. However, less severe disease processes, such as CPMA, can also cause PI.
Palavras Chave: Cow’s protein milk, necrotising enterocolitis