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1. Immunoallergology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Portugal.
2. Allergen and Immunotherapy Interest Group, Sociedade Portuguesa de Alergologia e Imunologia Clínica, Portugal.
3. Immunoallergology Department, Faculdade de Medicina da Universidade do Porto, Portugal.
4. Immunoallergology Department, Hospital de São Bernardo, Setúbal, Portugal.
5. Immunoallergology Unit, Hospital do Espírito Santo de Évora, Portugal.
6. Immunoallergology Unit, Hospital de Portimão, Centro Hospitalar Universitário do Algarve, Portugal.
7. Immunoallergology Unit, Hospital Professor Doutor Fernando Fonseca, Amadora-Sintra, Portugal.
8. Immunoallergology Unit, Hospital de Aveiro, Centro Hospitalar Baixo Vouga, Portugal.
9. Immunoallergology Department, Hospital de Santo António, Centro Hospitalar do Porto, Portugal.
10. Immunoallergology Unit, Hospital das Forças Armadas, Lisboa, Portugal.
11. Immunoallergology Unit, Hospital de Faro, Centro Hospitalar Universitário do Algarve, Portugal.
12. Immunoallergology Unit, Unidade Local de Saúde de Castelo Branco, Portugal.
13. Immunoallergology Department, Hospital Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central, Portugal.
14. Immunoallergology Department, Centro Hospitalar Universitário de São João, Porto, Portugal.
15. Immunoallergology Department, Centro Hospitalar Universitário Cova da Beira, Covilhã, Portugal.
16. Clinical Immunology Laboratory, Faculdade de Medicina, Instituto de Medicina Molecular, Universidade de Lisboa, Portugal.
17. University Clinic of Immunoallergology, Faculdade de Medicina da Universidade de Lisboa, Portugal.
18. Diater Laboratorio de Diagnostico y Aplicaciones Terapeuticas SA, Madrid, Spain.

- Publicação em versão integral J Investig Allergol Clin Immunol 2020 Jul 30;0. doi: 10.18176/jiaci.0533. Online ahead of print

Objective: To analyze component resolved diagnosis to Dermatophagoides pteronyssinus (Der p) in patients with respiratory allergy and its relationship with clinical severity in different geographical areas.
Methods: 217 patients (mean age 25.85±12.7 years; 51.16% females) were included, selected from 13 centers in Portugal (5 from North, n=65). All had allergic rhinitis, with or without asthma, and had positive skin prick tests to at least one dust mite. Specific IgE (sIgE) to Der p, Dermatophagoides farinae, Lepidoglyphus destructor, Der p1, Der p 2, Der p 10 and Der p 23 were determined by ImmunoCAP. Statistical analysis (Mann Whitney U test) compared patients with rhinitis vs rhinitis and asthma; mild vsmoderate-to-severe rhinitis; North vs South.
Results: Prevalence of sensitization was 98.2% to Der p, and 72.4%, 89.4%, 9.7% and 77% to Der p 1, Der p 2, Der p 10 and Der p 23, respectively. Corresponding median sIgE levelswere 8.56, 17.7, 0.01 and 3.95 kUA/L. sIgE to all allergens was higher in patients with moderate-to-severe rhinitis and rhinitis with asthma but not statistically significant (NSS). sIgE to Der p 2 was significantly higher in the South when compared with the North (p=0.0496).
Conclusions: sensitization to Der p is the most common in Portugal. Der p 2 had the highest prevalence and median sIgE levels. All sIgE to molecular components were higher in more symptomatic patients (NSS). sIgE to Der p 2 was higher in the South, which may be related to the warmer temperature and/or the larger sample size.

Palavras Chave: Allergy; Asthma; Component Resolved Diagnosis; Dermatophagoides pteronyssinus; Dust Mites; Rhinitis