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2023

ANUÁRIO DO HOSPITAL
DONA ESTEFÂNIA

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HYPOGONADOTROPIC HYPOGONADISM DUE TO COMPOUND HETEROZYGOUS MUTATIONS TACR3 IN SIBLINGS

Rita Valssassina 1, Filipa Briosa 1, Joana Soares 2, Marta Amorim3, Catarina Limbert 4

1. Department of Pediatrics, Hospital Beatriz Ângelo, Loures, Portugal
2. Department of Pediatrics, Hospital de Santo André, Leiria, Portugal
3. Department of Genetics, Hospital Dona Estefânia, Lisboa, Portugal
4. Department of Pediatric Endocrinology, Hospital Dona Estefânia, Lisboa, Portugal

- Revista John Wiley & Sons Ltd , secção Clinical Case Reports, publicação em versão integral

Resumo: The authors present a new association of two heterozygous TACR3 mutations (p.Arg230His and p.Trp275*) responsible for a clinical trait of normosmic congenital hypogonadotropic hypogonadism in a family

Palavras Chave: endocrinology and metabolic disorders, genetics, pediatrics and adolescent medicine