1 - Immunoallergology Service, Hospital de Dona Estefânia, Centro Hospitalar Universitário de Lisboa Central E.P.E., Lisbon, Portugal
2 - NOVA Medical School, Comprehensive Health Research Center (CHRC), Lisbon, Portugal 
- Publicação em versão integral EUR ANN ALLERGY CLIN IMMUNOL VOL 52, N.4, 148-159, 2020
Abstract: In the last years, disease classification of chronic respiratory diseases (CRD) has been viva- ciously discussed and new concepts have been introduced, namely asthma-chronic obstruc- tive pulmonary disease (COPD) overlap (ACO). Controversially the GOLD consensus document of 2020 considered that we should no longer refer to ACO, as they constitute two different diseases that may share some common traits and clinical features. The treatable traits approach has numerous strengths that are applicable to several levels of health care. In this paper we review the application of the treatable traits to CRD and de- scribe in detail the ones already identified in patients with asthma and COPD. Treatable traits in CRD can be divided in pulmonary, extra-pulmonary and behavior/lifestyle risk factors. Patients with both asthma and COPD have clearly recognized treatable traits in all these subtopics but it is notorious the severe and frequent exacerbations, the associated cardiovascular disease and the low health related quality of life and productivity of these patients.
Palavras Chave: Asthma; Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome; comorbidity; diagnosis; differential;