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2023

ANUÁRIO DO HOSPITAL
DONA ESTEFÂNIA

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FATAL MENINGITIS IN PATIENT WITH X-LINKED CHRONIC GRANULOMATOUS DISEASE CAUSED BY VIRULENT GRANULIBACTER BETHESDENSIS

Mafalda Rebelo1, Li Ding2, Ana Isabel Cordeiro1, Conceição Neves1, Maria João Simões3, Adrian M. Zelazny2, Steven M. Holland2, João Farela Neves1,4

1 - Hospital Dona Estefânia Centro Hospitalar de Lisboa Central, Entidade Publica Empresarial, Lisbon, Portugal (M. Rebelo, A.I. Cordeiro, C. Neves, J.F. Neves)
2 - National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Bethesda, Maryland, USA (L. Ding, A.M. Zelazny, S.M. Holland);
3 - National Institute of Health Dr. Ricardo Jorge, Lisbon
4 - Chronic Diseases Research Center, NOVA Medical School, Lisbon

Publicação Emerging Infectious Diseases, Volume 25, No 5, Maio 2019

Resumo: Granulibacter bethesdensis is a pathogen reported to cause recurrent lymphadenitis exclusively in persons with chronic granulomatous disease. We report a case of fatal meningitis caused by a highly virulent G. bethesdensis strain in an adolescent in Europe who had chronic granulomatous disease.

Palavras Chave: adolescente, chronic granulomatous disease, granulibacter bethesdensis, meningites, recurrent lymphadenitis