1 - Neonatal Intensive Care Unit, Dona Estefânia Hospital, Centro Hospitalar de Lisboa Central, EPE;
2 - Epidemiology & Statistics Consulting Core, Research Unit, Centro Hospitalar de Lisboa Central;
3 - Faculdade de Ciências Médicas, Universidade Nova de Lisboa.
- Jornadas da Secção de Neonatologia da SPP 2012.02/03. Lisboa (Comunicação oral).
- Fungal infections in Paediatrics and Neonates 2012.7-9/06 Londres. (Comunicação oral por convite).
- 20th European Workshop on Neonatology 2012. 27-30/06. Tallinn. (Comunicação oral).
- 3th UENPS meeting 2012. 14-17/11. Porto. (Poster).
- J Neonatal-Perinatal Med 2012: 5: 199.
Background: To draw guidelines on prophylaxis of fungal infection is important to define risk factors.
Objective: To assess risk profile for invasive fungal infection (IFI) in a population of a medical-surgical NICU.
Methods: Characterization of newborn infants (NB) with IFI (January 2002-December 2011)
Results: There were twelve episodes in twelve NB (4.6 episodes/1000 admissions). Median of gestational age and birth weight were 33wks (24–40) and 2091g (600–3660g). Seven NB had been operated, four had immunodeficiency, one was a great premature. CVC, TPN, large spectrum antibiotics were previous/actual conditions; prophylactic therapy was not used. Eight NB had positive blood culture, four only positive urine culture. Seven NB had C.albicans, four C.parapsilosis, one C. tropicalis. Lethality was 8%. RR for surgical patients was 4.15(IC95%:1.32-13.02). Incidence in bladder exstrophy, posterior urethral valves and diaphragmatic hernia were respectively 33.3%, 12.5% and 4.9%.
Conclusion: Prophylaxis guidelines should consider different risk conditions for IFI
Key-words: Neonatal intensive care units, fungal infection, risk factors.