1 - Allergy and Clinical Immunology Unit, Hospital de Dona Estefânia, Centro Hospitalar de Lisboa Central, E.P.E., Lisbon, Portugal
2 - CEDOC, Integrated Pathophysiological Mechanisms Research Group, Nova Medical School, Portugal
- Reunião Internacional
- Apresentação sob a forma de Póster em International Severe Asthma Forum, Madrid, Espanha, 8 a 10 de Novembro, 2018
- Prémio “poster prize for an outstanding poster presentation “
Introduction: Understanding severe asthma phenotypes may help clinicians find more effective treatments and lead to a better control of the disease.
Objectives: Our aim was to identify different severe asthma phenotypes in a sample of patients followed at our outpatient clinic.
Methods: In a sample of 30 severe asthma patients (defined according to the ERS/ATS) followed at a tertiary hospital we conducted a two-cluster analysis in order to identify different groups of patients. The considered variables were gender, age, atopy, body mass index (BMI), blood eosinophils (cells/mm3), total IgE and FEV1/FVC ratio.
Results: Twelve (40%) out of 30 patients were males and the median age of the sample was 16 years (P25-P75: 11-45 years). We identified four clusters of patients. Their characteristics are presented in the following table:
|
Cluster 1 |
Cluster 2 |
Cluster 3 |
Cluster 4 |
p-value |
|
|
Gender (male); |
12 /100% |
0 /0% |
0 / 0% |
0 / 0% |
<0.001 |
|
Atopy; |
12 /100% |
8 / 100% |
7 / 100% |
0 / 0% |
<0.001 |
|
Age (years); |
14 (12-29) |
10 (9-16) |
46 (43-52) |
36 (26-52) |
0.005 |
|
Blood eosinophils median |
395 (210-655) |
575 (415-825) |
250 (95-345) |
120 (85-1460) |
0.084 |
|
BMI median |
18 (16-26) |
17 (16-18) |
34 (31-37) |
28 (24-34) |
0.002 |
|
Total IgE |
665 (448-1300) |
843 (449-885) |
200 (72-296) |
30 (18-204) |
0.011 |
|
FEV1/FVC |
0.70 (0.65-0.83) |
0.80 (0.71-0.89) |
0.68 (0.66-0.70) |
0.64 (0.60-0.68) |
0.137 |
Conclusions: Despite the small sample we were able to identify four clusters. Clusters with younger patients (1 and 2) presented higher values of total IgE and lower BMI than the clusters with older patients. Patients from the clusters 3 and 4, were older, non-atopic and females.