1 - Serviço de Imunoalergologia, Área da Criança, Mulher e Adolescente, Hospital de Dona Estefânia, Centro Hospitalar de Lisboa Central, EPE, Lisboa
2 - Serviço de Patologia Clínica do Hospital de São José, Centro Hospitalar de Lisboa Central, EPE, Lisboa
3 - CEDOC, Integrated Pathophysiological Mechanisms Research Group, Nova Medical School
- Reunião Internacional, apresentação sob a forma de Póster em EAACI Congress 2018, Munique, Alemanha
Resumo:
Background: PR‐10 protein group sensitization is found in patients with respiratory allergy, mainly in areas inhabited by trees of the Betulacea or Fagacea families. Its role in food allergy is, however, more frequently described in the context of cross reactivity.
Objectives: Our aim was to characterize the pattern of molecular sensitization of food allergic patients sensitized to PR‐10 protein group with Immu- noCap ISAC® (ISAC).
Method: A group of patients in whom ISAC study was performed between January 2009 and June 2017 were analyzed. Subjects with PR‐10 sensitizations and a concomitant history of plant food allergy (PFA) were selected and their clinical records reviewed.
Results: Out of 234 ISAC studies performed, only 16 were positive for PR‐10. Of the latter, 9 (56%) corresponded to patients with a positive history of PFA. Most common triggering food groups were fresh fruit (n = 7 patients), tree nuts and peanuts (n = 5), legumes and cereals (n = 2 each). Clinically, 3 patients had oral contact urti- caria (OCU), 4 had systemic non‐anaphylactic reactions (SNA), and 2 had a history of anaphylaxis. Two of the patients with OCU were sensitized only to PR‐10 and 1 was co‐sensitized to Profilin and LTP. The remaining patients, with more severe reactions, were all co‐sen- sitized to either LTP and/or Storage Proteins (SP). Only 2 of the 7 patients without PFA were co‐sensitized to LTP or SP versus 7 of 9 with PFA (P < 0.05).
Conclusion: PR‐10 sensitization is rare in our population. Approxi- mately half of the patients had allergy to plant foods, but the major- ity were co‐sensitized to LTP and/or SP. The few patients only sensitized to PR‐10 had minor reactions. Among the patients without plant food allergy, co‐sensitization to LTP and SP was significantly less common. According to these results, in our population, PR‐10 seems to be less relevant to food allergy, when compared to reported results from other European countries.
Palavras Chave: PR-10; alergia respiratória; alergia alimentar; ISAC