Sociedade Portuguesa de Neonatologia
- Poster presentation. 8th International Congress UENPS. Bucareste 3–5 Outubro 2018
Through the Portuguese-Neonatal Society a point-prevalence survey (PPS) was performed in Portuguese NICUs to evaluate antibiotics prescription.
Methods: Inquiry on antibiotics prescription covering seven days (October 2017, 16th to 22nd) was sent to 18 NICUs. Participation was voluntary and anonymous. All patients must be enrolled.
Results: Participation rate was 77.8% (14/18 NICUs).Out of the 234 patients enrolled (median of gestational age and birth weight 33weeks and 1825g), 67 were under antibiotics (28.6%) for a total of individual antibiotic prescriptions of 128 in 53 associations; 4 patients had two cycles of antibiotics during the week; 4 patients had only one antibiotic – acyclovir, meropenem, amoxicillin+clavulanic acid, vancomycin; 43 had association of two antibiotics the most frequent being ampicillin+gentamicin (n=32); 8 had 7 different combinations of three antibiotics among ampicillin, gentamicin, metronidazol, meropenem, cefotaxime and vancomycin. In 31 out of the 67 patients, prescription intended to treat early-onset infection/infectious risk (47%) . Days free of antibiotics were calculated to be 1104 out of 1471 in-hospital days (75.1%). Rate of antibiotics use was 25%. Four out of the 53 prescriptions in association may be considered as inadequate. Eleven patients had positive cultures: Coagulase negative Staphylococcus, Enterobacter cloacae, E. coli, S.aureus; Kl pn ESBL.
Conclusion: Prevalence of antibiotic prescription was low and days free of antibiotics was at a good level. As it would be expected according to the main reason to prescribe antibiotics, the most common association was ampicillin and gentamicin. Four out of the 53 associations could be subject of discussion.
Keywords: Antibiotic Prescription, Neonatal Intensive Care Units, One Week Point-Prevalence Survey.