1. Serviço de Imunoalergologia do Hospital de Dona Estefânia, Centro Hospitalar de Lisboa, E.P.E., Lisboa
- XXXVI Congress of the European Academy Allergology Clinical Immunology, 17-21/06/2017, Helsínquia, Finlândia
- Apresentação como poster; publicação de resumo
- Reunião Internacional
Introduction: Food protein induced enterocolitis syndrome (FPIES) is a non-IgE mediated gastrointestinal allergic disorder. Its clinical presentation encompasses non-immediate severe vomiting, diarrhea and dehydration. There are no specific biomarkers, making it a diagnostic challenge. Characterization of patients helps to provide more evidence regarding natural history and impact of this disease.
Objectives: To perform a retrospective study of children clinically diagnosed with FPIES between 2010 and 2016.
Results: 11 patients were included, seven boys and four girls, with a median age at diagnosis of six months. The most common offending foods were cow’s milk protein (CMP, n=5) and rice (n=2). Other foods were fish, egg, chicken, wheat, carrot and potato. Average time of symptom onset was 2.5 hours. The most frequent symptoms were vomiting (n=10) and diarrhea (n=4). Six patients had a history of hospital admission related to this problem. Seven patients had concomitant atopic diseases, being the most frequent allergic co-mobility atopic eczema (n=5). Skin prick tests and/or specific IgE to culprit foods were negative at diagnosis, except for one patient with low specific IgE to CMP. Another patient become sensitized to CMP during follow-up. Open food challenges were performed in 10 patients starting from six months of age. Resolution was achieved in 6 patients, at a medium age of 36 months.
Conclusions: This case series provides one more look at FPIES’ patients characterization, increasing the knowledge about this disease. FPIES is a severe disease that often leads to hospital admissions. Milk is the most frequent allergen in this series. A majority of children achieved clinical resolution at 3 years of age.
Palavras Chave: FPIES, Food allergy