1 CEDOC, Respiratory Research Group, Nova Medical School, Campo dos M artires da P atria, Lisbon, Portugal;
2 Serviço de Imunoalergologia, Hospital de Dona Estefânia, Centro Hospitalar de Lisboa Central, EPE, Lisbon, Portugal;
3 Epidemiology and Statistics Analisys Unit, Research Centre, Centro Hospitalar de Lisboa Central, EPE, Lisbon, Portugal;
4 CEAUL, Department of Biostatistic and Informatics, Nova Medical School, Campo dos M artires da P atria, 130, 1169-056, Lisbon, Portugal;
5 National Laboratory for Civil Engineering, Lisbon, Portugal;
6 Environmental Health Department, National Health Institute Doutor Ricardo Jorge – Lisboa, Lisbon, Portugal;
7 Environmental Health Department, National Health Institute Doutor Ricardo Jorge – Porto, Oporto, Portugal;
8 Institute of Public Health (ISPUP), University of Porto, Oporto, Portugal;
9 Hospital da Luz, Lisbon, Portugal;
10 Sorbonne Universite ́s, UPMC Univ Paris 06, INSERM, Institut Pierre Louis d’Epide ́miologie et de Sante ́ Publique (IPLESP UMRS 1136), Epidemiology of Allergic and Respiratory diseases department (EPAR), Medical School Saint-Antoine, F75012 Paris, France
- Pediatr Allergy Immunol 2016: 27: 299–306.
Background: Scarce information is available about the relationships between indoor air quality (IAQ) at day care centers (DCC), the estimated predisposition for asthma, and the actual wheezing susceptibility.
Methods: In the Phase II of ENVIRH study, 19 DCC were recruited after cluster analysis. Children were evaluated firstly using the ISAAC questionnaire and later by a follow-up questionnaire about recent wheezing. A positive asthma predictive index (API) was considered as predisposition for asthma. Every DCC was audited for IAQ and monitored for chemical and biologic contaminants.
Results: We included 1191 children, with a median age of 43 (P25–P75: 25–58) months. Considering the overall sample, in the first questionnaire, associations were found between CO2 concentration (increments of 200 ppm) and diagnosis of asthma (OR: 1.10; 95% CI: 1.00–1.20). Each increment of 100 lg/m3 of total volatile organic compounds (TVOC) and 1 lg of Der p1/g of dust were associated with wheezing in the previous 12 months (OR: 1.06; 95% CI: 1.01–1.11 and OR: 1.06; 95% CI: 0.99–1.12, respectively). In the follow-up questionnaire, TVOC were again associated with wheezing (OR: 1.05; 95% CI: 1.00–1.11). Children exposed to fungal concentration above the 75th percentile had also higher odds of wheezing at follow-up. TVOC were associated with wheezing in children with either negative or positive API. Conclusions: IAQ in DCC seems to be associated with wheezing, in children with and without predisposition for asthma.
Palavras-chave: asthma; asthma predictive index; day care center; indoor air quality; volatile organic compounds; wheezing